TV host Savannah Guthrie never showed up for work. Police believe her mother was kidnapped.

On Monday morning, viewers of the US Today show noticed something was wrong. Co-host Savannah Guthrie didn't appear on screen.

Moments later, her colleagues addressed her absence, revealing that Guthrie is living every family's worst nightmare.

Her mother, Nancy Guthrie, 84, is missing — and authorities allege she was kidnapped from her bed.

"We do believe that Nancy was taken from her home against her will," Pima County Sheriff Chris Nanos confirmed in a press conference on Tuesday (Wednesday morning in Australia).

Nancy was last seen by family just before 10pm on Saturday evening, police have confirmed. When she failed to show up to church the next morning, her family went to Nancy's home.

She was nowhere to be seen.

The family reported her missing at around 12pm on Sunday. The search is ongoing.

According to the Associated Press, many of Nancy's belongings remained at her Tucson home, including her mobile phone, wallet, car and medication.

The publication also reports that signs of forced entry had been found at the home.

Although Nancy was of sound mind, officials say her limited mobility led them to believe she would not have left on her own.

"This is not dementia-related. She's as sharp as a tack," Nanos said in a press conference, per Associated Press. "The family wants everyone to know that this isn't someone who just wandered off.

"We know she didn't just walk out of there, that we know," he added, "There are other things at the site, at the scene, that indicate that she did not leave on her own."

Nanos added that Guthrie requires daily medication, without which she may die.

"If she's alive right now, her meds are vital. I can't stress that enough. It's been [more] than 24 hours and the family tells us if she doesn't have those meds, it can become fatal," Nanos said.

Savannah, who was born in Australia but raised in the US, has always spoken fondly of her mum and even invited her to join her on her morning show several times.

She's become a beloved member of the Today family.

Savannah Guthrie is pleading for prayers for her mother's safe return. Image: Instagram/ @savannahguthrie

In a post to her Instagram, Savannah referred to her mother as "a woman of deep conviction" and pleaded with those around her to pray for her mother's safe return.

"Thank you for lifting your prayers with ours for our beloved mum, our dearest Nancy, a woman of deep conviction, a good and faithful servant," she wrote. "Raise your prayers with us and believe with us that she will be lifted by them in this very moment."

"We need you," she said in a message to her mum, adding, "Bring her home."

Speaking at the press conference, Nanos echoed Savannah's sentiment.

"We have someone's life who is in jeopardy," he said. "We've got to find her and we've got to work hard to do that."

The FBI has joined the Pima County Sheriff's Office for the ongoing investigation as they continue their search for Nancy.

Tucson FBI chief, John Edwards revealed during the press conference, that they were making efforts to find her including "downloading and analysing cell phones, obtaining cell tower information, conducting interviews and providing any and all investigative support that the Sheriff's department needs."

Edwards explained that the officials are "looking at this from every angle" but pleaded with the community for help.

Police are urging anyone in the public with information to come forward.

"Please help us bring Nancy Guthrie home," he said.

Feature image: Instagram/ @savannahguthrie