Nine people are fighting for life after a stabbing incident on a London-bound train.

Ten people have been taken to hospital and nine are critically injured after a stabbing rampage on a British train.

Two suspects were arrested after the incident on the train at Huntingdon station, around 120km north of London, on Saturday night (Sunday morning AEDT).

"We can confirm that at 7.42pm today (Saturday) British Transport Police were called to reports of a multiple stabbing on board the 6.25pm train service from Doncaster to London King's Cross," British Transport Police said in a statement.

"Officers immediately attended Huntingdon station alongside paramedics.

"Armed police from Cambridgeshire Police boarded the train and arrested two people in connection to the incident who have been taken to police custody," the statement said.

"Ten people have been taken to hospital with nine believed to have suffered life-threatening injuries. There have been no fatalities.

"This has been declared a major incident and Counter Terrorism Policing are supporting our investigation whilst we work to establish the full circumstances and motivation for this incident."

Witnesses said they saw a man with a large knife and passengers hiding in the toilets to escape the rampage, The Times reported.

There was "blood everywhere" and people were getting "stamped" on by others as they tried to flee the horror, a witness told the paper.

"I heard some people shouting we love (you)."

We are currently responding to an incident on a train to Huntingdon where multiple people have been stabbed.

Officers are in attendance alongside @CambsCops and two people have been arrested.

Further updates will be shared here.

— British Transport Police (@BTP) November 1, 2025

The Sun said another witness said the attack "sparked pure panic on board".

"There was blood everywhere, it was a terrible scene, really violent. It was like something from a film," the witness told the paper.

Video footage on social media showed scores of blue-light police cars and emergency vehicles in a station car park, and a team of armed police running towards the stationary train at Huntingdon station.

The attack is understood to have started shortly after the LNER train left Peterborough station.

"The appalling incident on a train near Huntingdon is deeply concerning," Prime Minister Keir Starmer said in a statement on X.

The appalling incident on a train near Huntingdon is deeply concerning.

My thoughts are with all those affected, and my thanks go to the emergency services for their response.

Anyone in the area should follow the advice of the police.

— Keir Starmer (@Keir_Starmer) November 1, 2025

"My thoughts are with all those affected, and my thanks go to the emergency services for their response.

Huntingdon Station is closed, National Rail said, with all lines blocked.

Shadow home secretary Chris Philp urged the police and the government to provide an update on who has been arrested "as soon as possible".

"Horrific scenes in Huntingdon, in what seems to be a brutal mass attack by two perpetrators," he said on X.

Horrific scenes in Huntingdon, in what seems to be a brutal mass attack by two perpetrators

My thoughts are with all those injured or affected and the emergency services responding

The police and government should provide an update on what happened and who has been arrested as…

— Chris Philp MP (@CPhilpOfficial) November 1, 2025

British Transport Police said on X it was "responding to an incident on a train to Huntingdon where multiple people have been stabbed".

"Officers are in attendance alongside @CambsCops and two people have been arrested."

Cambridgeshire Constabulary said two men were arrested after the train was stopped at Huntingdon.

"Armed officers attended and the train was stopped at Huntingdon, where two men were arrested. A number of people have been taken to hospital."

Home Secretary Shabana Mahmood said she was "deeply saddened" to hear of the stabbings.

"I urge people to avoid comment and speculation at this early stage," she said.

London North Eastern Railway, which operates East Coast Mainline services in the UK, confirmed the incident had happened on one of its trains and has urged passengers not to travel because of "major disruption".

"We are experiencing major disruption across the LNER route. Emergency services are dealing with an incident at Huntingdon station, all lines are blocked," it said on X.

"Our advice is, 'Do Not Travel'. Please defer your travel where you can."

-AAP

Featured image: AAP