The real reason Amy Schumer stopped taking Ozempic.

Amy Schumer has openly shared details of her Ozempic use in the past, as well as slamming celebrities who keep their own weight-loss drug regimens hidden in the shadows.

But the actress also made it clear that she stopped taking it soon after she started — and now, she has explained why.

Watch: The Netflix trailer for Amy Schumer: 'Growing'. Post continues after video.

In a recent interview on The Howard Stern Show, the 43-year-old explained, "I have this gene, GDF15, which makes you extremely prone to nausea, which is why I was so sick during my pregnancy.

"So, I tried Ozempic almost three years ago and I was, like, bedridden. I was like, vomiting — and then you have no energy."

Though the actor lost around 13kg while taking the drug, the side effects of the Type II diabetes medication were too debilitating — and the actress felt as if she was "shrivelling away" due to extreme nausea.

"I lost 30 pounds so quick," she added. "I looked great, but I couldn't lift my head off the pillow. So, what's the point?"

Schumer clarified that while she herself had a bad experience with Ozempic, plenty of other people have found it helpful.

The 43-year-old first shared that she had tried Ozempic in 2023, while appearing on Watch What Happens Live with Andy Cohen.

At the same time, she had a message for the celebrities who are allegedly lying about taking it.

"Everyone and their mum's gonna try it. Everybody's lying. Everybody's like 'Oh, [it's] smaller portions'. Shut the f**k up, you're on Ozempic or one of those things, or you got work done. Just stop," Schumer said.

"Be real with the people. When I got lipo, I said I got lipo."

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Ozempic is the brand name for semaglutide, an antidiabetic medication that has been co-opted by the weight loss industry.

A once-a-week injection, the role of the drug is to balance blood sugar levels, making it an effective solution for long-term weight management for diabetics and obesity.

However, for many celebrities, it's become the drug of choice for weight loss.

Not, however, for Schumer, who "felt so sick and couldn't play with [her] son".

The actress shares five-year-old son Gene with her husband Chris Fischer.

"I was so skinny, and he's throwing a ball at me, and [I couldn't]," she said.

The most common side effects of semaglutide include diarrhoea, vomiting, abdominal pain, nausea and constipation, according to Healthline.

Despite Schumer's message, so far, few celebrities have openly admitted to taking the drug.

In January 2023, comedian Chelsea Handler talked about it being used for weight loss in her own Hollywood circles, sharing her experience on the Call Her Daddy podcast.

She said she was unknowingly prescribed the drug, and quickly decided to step away from it.

"So, my anti-ageing doctor just hands it out to anybody. I didn't even know I was on it. She said, 'If you ever want to drop five lbs, this is good.'

"I came back from a vacation and I injected myself with it. I went to lunch with a girlfriend a few days later, and she was like, 'I'm not really eating anything. I'm so nauseous, I'm on Ozempic,'" Handler said.

She said she didn't realise semaglutide and Ozempic were the same thing until her friend explained.

"I'm not on it anymore. That's too irresponsible," Handler added.

"I'm not gonna take a diabetic drug. I tried it, and I'm not gonna do that. That's not for me. That's not right for me.

"Everyone is on Ozempic. It's gonna backfire, something bad is gonna happen."

Read more:

'I take diabetes medication for weight loss. Here's what I want you to know.'

In 2023, weight loss drugs are having a 'revolution'. But there's a lot we're not talking about.

Berberine has been called the 'natural Ozempic'. Here's what you need to know.

'Everyone is on Ozempic': Why Hollywood's newest weight loss trend is so concerning.

This article was originally published in June 2023 and has since been updated with new information.

Feature Image: Instagram/@amyschumer